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. 2016 Jun 21;14:47. doi: 10.1186/s12951-016-0201-1

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — FRA modulates HuR-FNP efficacy. a HuR-FNP-mediated growth inhibition of H1299 cells was diminished in the presence of excess of folic acid (1 mM) in the culture medium compared to HuR-FNP inhibition in the absence of excess folic acid. HuR-FNP-mediated inhibitory activity on the expression of b HuR protein and c mRNA expression levels were also abrogated the presence of excess of folic acid (1 mM) compared to HuR-FNP treatment in the absence of excess folic acid in H1299 cells. d HuR-FNP-mediated growth inhibition was less in CCD16 cells that was further diminished in the presence of excess of folic acid (1 mM). e HuR protein and f mRNA expression levels were not markedly affected in CCD16 cells in the presence of excess folic acid compared to in the absence of excess folic acid. (error bars denote SD; *p < 0.05; **p < 0.01)