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. 2016 Jun 21;4:32. doi: 10.1186/s40425-016-0138-9

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© Sridharan et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Trends in serum angiogenic cytokine concentrations comparing the beginning and end of treatment, as evaluated by non-parametric Wilcoxon signed rank tests. Each line represents an individual patient. Serum levels of Ang1 (p < 0.0001) and VEGF decreased (p < 0.0001) over the course of treament. In contrast, there were significant increases inserum levels of Ang2 (p < 0.0001) and PLGF (p < 0.0001)