Skip to main content
. Author manuscript; available in PMC: 2017 Apr 1.
Published in final edited form as: J Bone Miner Res. 2016 Jan 20;31(4):890–899. doi: 10.1002/jbmr.2740

Figure 4.

Figure 4

(A and B) Osteocyte apoptosis and RANKL expression in fatigued mouse ulnae treated in vivo with the P2X7R antagonist, Brilliant Blue G (BBG) or Vehicle (VEH). BBG inhibited the normal increase in osteocyte RANKL expression in ulnar cortex following fatigue loading (p<0.05), but did not alter the amount of osteocyte apoptosis. (C and D) BBG treatment dramatically reduced the activation of resorption after fatigue at both intracortical (Rs.N, p<0.06 vs VEH) and endocortical (En.Tun.N, p<0.05 vs VEH) locations.