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. Author manuscript; available in PMC: 2017 May 15.
Published in final edited form as: Cancer Res. 2016 Mar 24;76(10):2944–2953. doi: 10.1158/0008-5472.CAN-15-1675

Figure 5. Gβγ binding to p110β is important for breast cancer cell extravasation in vitro and in vivo.

Figure 5

A) The number of metastases per lung section from SCID mice injected with MDA-MB-231 cells expressing wild type or mutant p110β into the lateral tail vein. B) Average size of lung metastases. The data represent the mean ± SEM from 4, 6, and 5 mice for wild type p110β, p110βKK-DD, or p110βK-R, respectively. Macrophage-stimulated transmigration of (C) MDA-MB-231 or (D) BT-549 cells expressing wild type or mutant p110β in the eTEM assay is expressed as the fold change in the number of transmigrated cells relative to values obtained from cells expressing wild type p110β. The data represent the mean ± SEM from three independent experiments. *: p<0.05; **: p<0.01; ***: p<0.001; ****: p<0.0001; ns: not significant.