[11C]WAY100635 binding potential (BPF) estimates for the 5-HT1A receptor in male control and male MDD subjects in the raphe nuclei. Blue diamonds or red squares represent single measurements of raphe BPF in control and MDD subjects, respectively. Thin-capped vertical error bars represent weighted standard errors. Weighed group mean and standard error of the weighed mean of BPF are represented by thick horizontal lines and thick vertical lines, respectively. BPF, binding potential; [11C]WAY100635, N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl)cyclo-hexanecarboxamide; 5-HT1A, serotonin-1A receptor.