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The effects of morphine dependence in Sprague-Dawley and Wistar-Kyoto rats. (a) Average norepinephrine clearance as measured by t1/2. (b and c) Average evoked norepinephrine ([NE]max) following administration of 2 mg/kg BRL-44408 (b), or guanfacine (GFC) (c) relative to pre-drug stimulated release. Data are presented as mean±SEM. Bonferroni post hoc analysis: *P<0.05, **P<0.01, ***P<0.005.
