Table 2. Anxiety-like Behavior Following Differing Stressors.
| Ratio Open/Closed time | Total entries | Open time | Closed time | |
|---|---|---|---|---|
| Social isolation | ||||
| Sprague-Dawley | ||||
| Pair-housed (n=7) | 0.33±0.09 | 14±1 | 49±11 s | 163±10 s |
| Single-housed (n=8) | 0.12±0.05* | 12±2 | 20±7 s* | 201±12 s* |
| Wistar-Kyoto | ||||
| Pair-housed (n=8) | 0.26±0.06 | 9±2 | 38±8 s | 156±10 s |
| Single-housed (n=8) | 0.23±0.04 | 9±1 | 32±6 s | 148±9 s |
| Coerulean Lesioning | ||||
| Sprague-Dawley | ||||
| Saline (n=8) | 0.26±0.01 | 15±2 | 47±6 s | 165±8 s |
| DSP-4 lesioned (n=8) | 0.12±0.03* | 6±2* | 25±6 s* | 207±15 s* |
| Wistar-Kyoto | ||||
| Saline (n=8) | 0.17±0.05 | 6±1 | 25±8 s | 162±8 s |
| DSP-4 lesioned (n=7) | 0.13±0.03 | 7±3 | 24±4 s | 193±14 s |
Total number of entries and time spent in the open and enclosed arms of the elevated plus maze was evaluated. An animal's preference for open arms was expressed as a ratio of open-arm time over closed-arm time. Data are presented as mean±SEM. Treated animals were compared with their controls using a two-way ANOVA with Bonferroni post hoc analysis. Differences in anxiety following stress were determined for each strain by comparing treated animals with their respective controls. Starred values denote significance between the treated group and the control directly above it. *P<0.05.