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. 2015 Feb 11;40(7):1762–1771. doi: 10.1038/npp.2015.24

Figure 4.

Figure 4

Effects of R-MOD on basal and nicotine-enhanced DA in the nucleus accumbens in rats with nicotine self-administration history. (a) The general experimental procedures; (b) extracellular DA levels before and after R-MOD and/or nicotine administration, illustrating that both drugs elevated extracellular DA levels. (c) Nicotine-induced changes in extracellular NAc DA (fmol/sample) in the presence or absence of R-MOD pretreatment, by subtracting basal level (mean value of two samples before nicotine) of extracellular DA from DA level after nicotine administration; (d) nicotine-induced % changes in DA over baseline (mean value of two samples before nicotine injection) in the presence or absence of R-MOD pretreatment, illustrating a significant reduction in nicotine-enhanced extracellular DA in a dose-dependent manner after R-MOD administration. *p<0.05; compared with baseline before R-MOD (a) or nicotine (b, c) administration; #p<0.05, compared with vehicle control group.