Table 1.
BK auxiliary subunits in glomerulus.
| Subunit | Gene symbol | Tissue (s) | Functional effect |
|---|---|---|---|
| β1 | KCNMB1 | Mesangial cell; rat podocyte | Facilitates voltage-sensor activation; IbTX insensitive; ChTX sensitive (Ma et al., 2005; Piwkowska et al., 2015) |
| β2 | KCNMB2 | Rat podocyte | Inactivation; IbTX sensitive; ChTX insensitive (Piwkowska et al., 2015) |
| β3 | KCNMB3 | Human podocyte | Inactivation; IbTX sensitive; ChTX insensitive (Morton et al., 2004) |
| β4 | KCNMB4 | Rat and human podocyte | Facilitates voltage-sensor activation; IbTX insensitive; ChTX insensitive; MarTX sensitive (Morton et al., 2004; Kim et al., 2008; Piwkowska et al., 2015) |
| γ1 | LRRC26 | Arterial smooth muscle cell | Facilitates voltage-sensor activation; IbTX sensitive (Contreras et al., 2013) |
| γ2 | LRRC52 | Kidney | Facilitates voltage-sensor activation (Contreras et al., 2013) |
| γ3 | LRRC55 | Not reported | Facilitates voltage-sensor activation (Contreras et al., 2013) |
| γ4 | LRRC38 | Not reported | Facilitates voltage-sensor activation (Contreras et al., 2013) |