Figure 1.
FAK modulates steady state levels of adhesive force. (A) Adhesion profiles showing the fraction of adherent cells as a function of applied shear stress for FAK-expressing (FAK+) and FAK-null (FAK−) cells. Experimental values (FAK+, gray circles; FAK-, gray squares) were fit to a sigmoid curve (fitted values: FAK+, filled circles; FAK− empty circles) to obtain the shear stress for 50% detachment, indicated by vertical lines. (B) Mean adhesion strength values showing increased adhesive force for FAK− cells (average ± standard deviation).