Table 2.
Antimicrobial susceptibility profiles of carbapenem-non-susceptible Enterobacteriaceae
| Antimicrobial agent and MIC(µg/mL) | ||||||||||||
| Isolatea |
MH Tb |
Genoty pe |
Ertapenem | Imipenem | Gentamicin | Tobramycin | Piperacillin/tazobactam | Ceftriaxone | Ceftazidime | Cefepime | Ciprofloxacin | Trimethoprim/sulfamethoxazole |
| KPN1 | + | blaIMP-4 | 4 | 8 | ≤1 | ≤1 | 8 | ≥64 | ≥64 | 32 | ≤0.25 | ≥320 |
| KPN2 | + | blaIMP-4 | ≥8 | 2 | ≥16 | 8 | 64 | ≥64 | ≥64 | ≥64 | 2 | ≥320 |
| KPN3 | + | blaIMP-4 | 4 | ≤1 | ≥16 | 8 | 8 | ≥64 | ≥64 | ≥64 | 1 | ≥320 |
| KPN4 | − | None | 4 | 2 | ≥16 | 8 | 8 | ≥64 | ≥64 | 32 | 1 | ≥320 |
| KPN5 | + | blaIMP-4 | 4 | ≤1 | ≥16 | 8 | 8 | ≥64 | ≥64 | 8 | 0.5 | ≥320 |
| KPN6 | + | None | 4 | 8 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN7 | + | blaIMP-4 | ≥8 | ≤1 | ≥16 | 8 | 64 | ≥64 | ≥64 | 16 | 2 | ≥320 |
| KPN8 | + | blaIMP-4 | 4 | ≤1 | ≥16 | 8 | 32 | ≥64 | ≥64 | ≥64 | 2 | ≥320 |
| KPN9 | + | None | 4 | ≤1 | ≥16 | 8 | 16 | ≥64 | ≥64 | ≥64 | 2 | ≥320 |
| KPN1 0 |
+ | blaIMP-4 | ≥8 | ≤1 | ≥16 | 8 | 8 | ≥64 | ≥64 | 8 | 1 | ≥320 |
| KPN1 1 |
+ | blaIMP-4 | 4 | ≤1 | ≥16 | 8 | 8 | ≥64 | ≥64 | 8 | 2 | ≥320 |
| KPN1 2 |
+ | blaIMP-4 | 4 | 2 | ≥16 | 8 | 8 | ≥64 | ≥64 | ≥64 | 2 | ≥320 |
| KPN1 3 |
+ | None | 4 | ≤1 | ≥16 | 8 | 8 | ≥64 | ≥64 | 8 | 1 | ≥320 |
| KPN1 4 |
+ | blaIMP-8 | 4 | ≤1 | ≥16 | 8 | ≥128 | ≥64 | ≥64 | ≥64 | 1 | ≥320 |
| KPN1 5 |
+ | blaIMP-8 | 4 | 4 | 2 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN1 6 |
+ | blaIMP-8 | 4 | 4 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN1 7 |
+ | blaIMP-8 | 4 | 4 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN1 8 |
+ | blaIMP-8 | 4 | 4 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN1 9 |
+ | blaIMP-8 | 4 | 2 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN2 0 |
+ | blaIMP-8 | 4 | 4 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN2 1 |
+ | blaIMP-8 | 4 | 8 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN2 2 |
+ | blaIMP-8 | 4 | 4 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN2 3 |
+ | blaIMP-8 | 4 | 4 | 4 | 8 | 8 | ≥64 | ≥64 | ≥64 | ≤0.25 | ≥320 |
| KPN2 4 |
+ | blaIMP-8 | 4 | 2 | ≤1 | 8 | 8 | ≥64 | ≥64 | 16 | ≤0.25 | ≥320 |
| ECL1 | − | None | 4 | ≤1 | ≥16 | ≥16 | ≥128 | ≥64 | ≥64 | ≥64 | ≥4 | ≥320 |
| ECL2 | − | None | 4 | ≤1 | ≥16 | ≥16 | ≥128 | ≥64 | ≥64 | ≥64 | ≥4 | ≤20 |
| ECL3 | − | None | 4 | ≤1 | ≥16 | ≥16 | ≥128 | ≥64 | ≥64 | ≥64 | 0.5 | ≤20 |
| ECL4 | + | blaIMP-8 | ≥8 | 4 | ≤1 | ≤1 | 8 | ≥64 | ≥64 | 32 | ≤0.25 | ≥320 |
| KOX 1 |
− | blaIMP-4 | ≥8 | 8 | ≥16 | ≥16 | ≥128 | ≥64 | ≥64 | ≥64 | ≥4 | 80 |
| KOX 2 |
+ | blaIMP-4 | ≥8 | ≥16 | ≥16 | ≥16 | ≥128 | ≥64 | ≥64 | ≥64 | ≥4 | ≥320 |