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. Author manuscript; available in PMC: 2016 Jun 21.
Published in final edited form as: DNA Repair (Amst). 2009 Sep 24;8(11):1328–1332. doi: 10.1016/j.dnarep.2009.08.007

Fig. 3.

Fig. 3

Immune responses and affinity maturation in WT and Neil1−/− mice. Mice (8 WT and 8 Neil1−/−) were immunized with NP-CGG and analyzed for the production of NP-specific IgG z1 antibodies as described in Section 2. Open and solid circles represent WT and Neil1−/− mice, respectively. (A) Titers of total (high- and low-affinity) NP-specific antibodies. (B) Titers of high-affinity NP-specific antibodies. The reduced production of total and high-affinity antibodies in Neil1−/− mice relative to WT mice is statistically significant (p < 0.05, two-way ANOVA).