Table 5.
The list of up- and downregulated genes in the LDR 10 Gy group compared with the HDR 10 Gy group
| Gene expression | Gene symbol | Gene description | Biological process |
|---|---|---|---|
| Upregulated in LDR 10 Gy | ACTA2 | actin, α2, smooth muscle | vascular smooth muscle contraction |
| CD109 | GPI-anchored glycoprotein | negative regulation of transforming growth factor β receptor signaling pathway | |
| IL1RAP | IL-1 receptor accessory protein | immune response | |
| SLC7A11 | solute carrier family 7, member 11 | amino acid transport | |
| GDF15 | growth differentiation factor 15 | transforming growth factor β receptor signaling pathway |
|
| Downregulated in LDR 10 Gy | BMP4 | bone morphogenetic protein 4 | angiogenesis |
| THBS2 | thrombospondin 2 | negative regulation of angiogenesis | |
| TANC2 | tetratriopeptide repeat, ankyrin repeat and coiled coil-containing 2 | in utero embryonic development | |
| MKX | mohawk homeobox | muscle organ development | |
| GALNT13 | polypeptide N-acetylgalactosaminyl transferase 13 | integral component of membrane | |
| PRAME | preferentially expressed antigen in melanoma | apoptosis |
LDR 10 Gy = cells irradiated with 10 Gy at the low-dose rate, HDR 10 Gy = cells irradiated with 10 Gy at the high-dose rate.