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. 2016 Feb 19;65(7):1892–1903. doi: 10.2337/db15-1428

Figure 4.

Figure 4

Effects of liver-selective aPKC inhibitor ATM on resting/basal and insulin-stimulated phosphorylation/activity of aPKC and Akt and phosphorylation of Akt substrates FOXO1, FOXO3a, GSK3β, and mTOR in brains of wild-type (WT) control and Het-MλKO (KO) mice. Where indicated, ad libitum–fed mice were treated with insulin (1 unit/kg bw i.p.) 15 min before being killed. Where indicated, Het-MλKO mice were injected once daily for 8 days with aPKC inhibitor ATM (60 mg/kg bw s.c.), which reversed hyperinsulinemia (21). Portrayed values of phosphoproteins are reported as the mean ± SEM of 6 mice. *P < 0.05, **P < 0.01, and ***P < 0.001 (ANOVA) for comparison of values of indicated groups vs. values of the WT control group.