Figure 2.

Genes repressed in replicating β-cells are involved in β-cell function and maturation. A: GO analysis of genes downregulated in replicating β-cells. B: Significant overrepresentation of genes upregulated in development in genes repressed in replicating β-cells (FDR ≤0.05) and, conversely, of genes repressed in development in genes induced in replicating β-cells (FDR ≤0.05). C: Genes induced in maturation and repressed in replication are associated with β-cell function. Genes repressed in maturation and activated in replication are associated with cell cycle biological processes. Overrepresentation was computed using a statistical test based on hypergeometric distribution.