Table 3. ROC analysis of possible tear biomarkers for AD.
Proteins | Sensitivity (%) | Specificity (%) | PV+ (%) | PV- (%) | AUC | Accuracy | 95% CI |
---|---|---|---|---|---|---|---|
LCN1 | 53.1 | 79.7 | 22.7 | 43.3 | 0.68 | 0.72 | 0.56–0.80 |
LTF | 78.1 | 51.6 | 17.5 | 55.4 | 0.67 | 0.73 | 0.55–0.78 |
LYZ | 90.6 | 50 | 8.6 | 52.5 | 0.68 | 0.67 | 0.57–0.79 |
PIP | 71.9 | 56.2 | 20 | 54.9 | 0.6 | 0.67 | 0.48–0.72 |
LACRT | 90.6 | 57.8 | 7.5 | 48.2 | 0.71 | 0.65 | 0.59–0.82 |
DCD | 62.5 | 76.6 | 19.7 | 42.9 | 0.7 | 0.70 | 0.59–0.82 |
LCN1+DCD | 53.1 | 89.1 | 20.8 | 29.2 | 0.74 | 0.76 | 0.63–0.85 |
LYZ+LACRT | 90.6 | 59.4 | 7.3 | 47.3 | 0.72 | 0.64 | 0.61–0.83 |
LCN1+DCD+ LACRT | 90.6 | 65.6 | 6.7 | 43.1 | 0.8 | 0.69 | 0.71–0.89 |
LCN1+DCD+LTF | 53.1 | 89.1 | 20.8 | 29.2 | 0.74 | 0.76 | 0.62–0.84 |
LCN1+DCD+LYZ | 59.4 | 82.8 | 19.7 | 36.7 | 0.75 | 0.76 | 0.64–0.86 |
LCN1+LTF+LYZ | 87.5 | 50 | 11.1 | 53.3 | 0.72 | 0.71 | 0.61–0.83 |
LYZ+LACRT+ DCD | 90.6 | 65.6 | 6.7 | 43.1 | 0.79 | 0.71 | 0.69–0.89 |
LYZ+LACRT+ LCN1 | 87.5 | 59.4 | 9.5 | 48.1 | 0.72 | 0.67 | 0.62–0.83 |
PIP+LACRT+DCD | 93.8 | 60.9 | 4.9 | 45.5 | 0.79 | 0.68 | 0.69–0.97 |
DCD+LCN1+LTF+PIP | 62.5 | 76.6 | 19.7 | 42.9 | 0.74 | 0.72 | 0.64–0.84 |
LCN1+DCD+LYZ+LACRT | 81.2 | 76.6 | 10.9 | 36.6 | 0.8 | 0.72 | 0.71–0.89 |