Table 3. ROC analysis of possible tear biomarkers for AD.

Proteins	Sensitivity (%)	Specificity (%)	PV+ (%)	PV- (%)	AUC	Accuracy	95% CI
LCN1	53.1	79.7	22.7	43.3	0.68	0.72	0.56–0.80
LTF	78.1	51.6	17.5	55.4	0.67	0.73	0.55–0.78
LYZ	90.6	50	8.6	52.5	0.68	0.67	0.57–0.79
PIP	71.9	56.2	20	54.9	0.6	0.67	0.48–0.72
LACRT	90.6	57.8	7.5	48.2	0.71	0.65	0.59–0.82
DCD	62.5	76.6	19.7	42.9	0.7	0.70	0.59–0.82
LCN1+DCD	53.1	89.1	20.8	29.2	0.74	0.76	0.63–0.85
LYZ+LACRT	90.6	59.4	7.3	47.3	0.72	0.64	0.61–0.83
LCN1+DCD+ LACRT	90.6	65.6	6.7	43.1	0.8	0.69	0.71–0.89
LCN1+DCD+LTF	53.1	89.1	20.8	29.2	0.74	0.76	0.62–0.84
LCN1+DCD+LYZ	59.4	82.8	19.7	36.7	0.75	0.76	0.64–0.86
LCN1+LTF+LYZ	87.5	50	11.1	53.3	0.72	0.71	0.61–0.83
LYZ+LACRT+ DCD	90.6	65.6	6.7	43.1	0.79	0.71	0.69–0.89
LYZ+LACRT+ LCN1	87.5	59.4	9.5	48.1	0.72	0.67	0.62–0.83
PIP+LACRT+DCD	93.8	60.9	4.9	45.5	0.79	0.68	0.69–0.97
DCD+LCN1+LTF+PIP	62.5	76.6	19.7	42.9	0.74	0.72	0.64–0.84
LCN1+DCD+LYZ+LACRT	81.2	76.6	10.9	36.6	0.8	0.72	0.71–0.89