Figure 2.

Plasma concentrations of vitamin C (ascorbic acid) before (time = 0 minute) and after: (1) oral administration of placebo, (2) oral administration of 4 g of vitamin C encapsulated in liposomes, (3) oral administration of 4 g of unencapsulated vitamin C, and (4) intravenous administration of 4 g of vitamin C. (A) All treatments. (B) All treatments excluding intravenous administration. Twenty minutes of forearm ischemia was initiated at three hours. ^*P < 0.001 vs all other treatments; ^#P < 0.001 vs unencapsulated oral and placebo; and ^{^}P < 0.001 vs placebo. Data are mean ± SE (plasma vitamin C: 1 mg/dL = 56.78 μmol/L).