Table 1.
Baseline characteristics of T-ALL/LBL patients stratified by WHO immunophenotypic categories
| WHO categories | |||||
|---|---|---|---|---|---|
| Total | Early | Thymic | Mature | P value | |
| n | 111 | 44 | 48 | 19 | |
| Diagnosis | |||||
| ALL | 76 (68) | 34 (78) | 27 (56) | 15 (79) | |
| LBL | 35 (32) | 10 (22) | 21 (44) | 4 (21) | .05 |
| Age | 30 (13-79) | 29 (13-75) | 31 (17-79) | 28 (17-64) | .14 |
| Gender | |||||
| Female | 29 (26) | 9 (20) | 15 (31) | 5 (26) | |
| Male | 82 (74) | 35 (80) | 33 (69) | 14 (74) | .5 |
| Cytogenetics (n = 105) | |||||
| Diploid | 71 (68) | 24 (57) | 34 (74) | 13 (76) | .2* |
| Hyperdiploid | 5 (5) | 2 (5) | 2 (4) | 1 (6) | |
| Hypodiploid | 2 (2) | 2 (5) | |||
| Miscellaneous | 27 (25) | 14 (33) | 10 (22) | 3 (18) | |
| Presenting laboratory values | |||||
| WBC (×109/L) | 8.0 (0.4-292.3) | 5.5 (0.4-151.2) | 8.1 (1.8-292.3) | 8.6 (2.7-134.9) | .28 |
| WBC ≥100 (×109/L) | 8 (7) | 2 (5) | 5 (10) | 1 (5) | .52 |
| Platelet count (×109/L) | 127 (10-488) | 82 (10-391) | 197 (10-488) | 148 (22-402) | .14 |
| Hemoglobin (g/dL) | 11.4 (6.8-16.7) | 10.3 (6.8-16.7) | 11.3 (7.2-15.2) | 11.9 (8.8-16.1) | .21 |
| LDH (IU/L) | 938 (209-32 029) | 879 (209-11 300) | 1298 (285-32 029) | 834 (284-20 795) | .08 |
| CNS involvement at diagnosis | 6 (5) | 4 (9) | 1 (2) | 1 (5) | .33 |
| Treatment received | |||||
| Hyper-CVAD | 43 (39) | 15 (34) | 18 (38) | 10 (53) | |
| Hyper-CVAD + nelarabine | 44 (40) | 19 (43) | 19 (39) | 6 (31) | |
| Augmented BFM | 24 (21) | 10 (23) | 11 (23) | 3 (16) | |
Cytogenetics either not done or insufficient metaphases recovered for 6 patients. Miscellaneous cytogenetics included del(5q), del(6q), del(9p), and others.
*
Diploid vs other.