Table 1.

Study Entry Criteria

Inclusion Criteria Suspected stroke identified by the modified Los Angeles Prehospital Stroke Screen (Age ≥ 40; History of seizures or epilepsy absent; At prestroke baseline, patient not wheelchair-bound or bedridden; Blood glucose between 60 and 400; Unilateral face, arm, and/or grip weakness) Age 40–95, inclusive Last known well time within 2 hours of treatment initiation Deficit present for > 15 minutes

Exclusion Criteria Coma Rapidly improving neurologic deficit Pre-existing neurologic, psychiatric, or advanced systemic disease that would confound the neurological or functional outcome evaluations SBP < 90 or > 220 Known severe renal dysfunction (on dialysis or known chronic creatinine > 3.0) Severe respiratory distress (O2 sat < 90% or respiratory rate < 12 or > 24) Known second or third degree heart block with no pacemaker in place Major head trauma in the last 24 hours Recent stroke within prior 30 days Patient unable to give informed consent and no available legally authorized representative to provide informed consent and enrollment under exception from explicit consent not yet approved in catchment area