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. Author manuscript; available in PMC: 2016 Jun 21.
Published in final edited form as: Ann N Y Acad Sci. 2010 Nov 9;1214:156–167. doi: 10.1111/j.1749-6632.2010.05819.x

Figure 3.

Figure 3

Genes that cause MCPH localize to the centrosome during the cell cycle and play a role in neurogenesis. During neurogenic proliferation, progenitors first undergo symmetric cell division where two daughter cells of progenitor fate are produced. This is followed by asymmetric cell division in which one daughter cell follows a progenitor cell fate and the other follows a neural fate.29,102–104 Committed neurons then migrate to the cortical plate (CP). The cell cycle is critically regulated by the mitotic machinery,29,105,106 and each of the five MCPH genes (MCPH1, APSM, STIL, CENPJ, and CKD5RAP2) colocalize with the mitotic apparatus during at least some part of the cell cycle. Genetic studies reveal that MCPH is primarily a disorder of cortical neurogenesis and not a disorder of migration, cell death, or cell growth and provide insight into the genes that regulate brain size in humans.