Fig. 7.

(a, b) Mean effects plots for (a) Max. dV_m/dt and (b) APD₉₀ emulators, showing how varying each input in the range from 0 to 1 influences the expected value of the emulator output. (c, d) Cumulative effect of changing the variance of inputs on emulator outputs. (c) Distributions of Max. dV_m/dt when G_Na was reduced from 0.04 (red), to 0.02 (blue), 0.01 (green), and 0.005 (yellow) while the variance of all other inputs was maintained at 0.04 normalised units. (d) Distributions of APD₉₀ when the variance of all inputs was initially set to 0.001 normalised units, and then the variance of G_Kr (red), G_Ks (blue), G_CaL (green), and then τ_f multiplier (yellow) were set to 0.04 normalised units.