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. Author manuscript; available in PMC: 2017 Aug 1.
Published in final edited form as: Int Immunopharmacol. 2016 Jan 8;37:31–42. doi: 10.1016/j.intimp.2015.12.034

Table 1.

Summary of in vivo studies examining the effects of oral creatine on inflammation

Species Model Dose Results Reference
Rat Carrageean-induced edema
Nystatin-induced edema
5-HT-induced edema
Formaldehyde-induced arthritis
Granuloma pouch		 50-500 mg kg−1
500 mg kg−1
500 mg kg−1
100-500 mg kg−1
100 mg kg−1 ×7d		 Reduced swelling
Reduced swelling
Reduced paw volume
Reduced paw volume
Reduced exudate, reduced pouch weight		 [19]
Mouse OVA sensitization 0.5 g kg−1d−1 Increased allergic inflammation, airway responsiveness, airway remodeling [24]
Mouse OVA sensitization ± exercise 0.5 g kg−1d−1 Low intensity exercise reduced negative effects of creatine [220]
Mouse OVA sensitization 0.5 g kg−1d−1 Increased allergic inflammation and airway remodeling [221]