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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Horm Behav. 2016 May 10;83:60–67. doi: 10.1016/j.yhbeh.2016.05.001

Figure 2. Letrozole reduces hippocampal E2 levels at a dose that impairs spatial and object recognition memory consolidation.

Figure 2

Mice receiving bilateral dorsal hippocampal infusion of 0.025 μg letrozole had significantly lower dorsal hippocampal E2 levels than vehicle-treated mice 30 min after infusion (*p < 0.05; vehicle n=3; letrozole n=6). Dorsal hippocampal E2 levels in vehicle-treated mice dropped to the level of those in letrozole-treated mice by 60 min after training, and were similar to that of letrozole-treated mice at the 60 min (vehicle n=3; letrozole n=7) and 120 min (vehicle n=3; letrozole n=5) time points. Dashed horizontal line indicates the average background estradiol concentration as reported by EIA for control wells; all estradiol levels above this concentration are validated as detectable levels on the EIA.