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Early IGFBP2 expression drives HGG. A. Kaplan-Meier survival curves for Ntv-a mice injected with RCAS-PDGFB, RCAN-TRE-IGFBP2, and RCAS-Tet-On. IGFBP2 induction was mediated by doxycycline (dox) administration at the times indicated (arrows). B, C. Age of animals at the time of symptom development in each group. High-grade gliomas are indicated with red symbols. C. Plot showing only high-grade gliomas from each group.
