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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Pathol. 2016 Jun 10;239(3):355–364. doi: 10.1002/path.4734

Figure 2.

Figure 2

Inducible IGFBP2-driven tumours resemble human glioma. Representative H&E-stained sections and immunohistochemical staining of sections from mice with and without doxycycline-mediated IGFBP2 induction. Lower grade gliomas (LGGs) display uniform round nuclei and a characteristic “fried egg” appearance (grey arrows). High-grade gliomas (HGGs) display pseudopalisading necrosis (black arrows). Arrowheads indicate regions of high cellularity with intense IGFBP2 and LSD1 concordant staining. Insets represent higher magnification of the outlined regions, scale bar is 100 μm.