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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: J Pathol. 2016 Jun 10;239(3):355–364. doi: 10.1002/path.4734

Figure 3.

Figure 3

IGFBP2 inhibition impairs tumour progression. A. Kaplan-Meier survival curves for Ntv-a mice injected with RCAS-PDGFB, RCAN-TRE-IGFBP2, and RCAS-Tet-On. IGFBP2 induction is mediated by doxycycline administration from birth, and the duration of doxycycline-mediated IGFBP2 expression is indicated by the dotted lines. B. Size of tumours relative to IGFBP2 status. Animals were grouped on the basis of overall IGFBP2 induction. ** p= 0.0019 comparing all three groups by the Kruskal-Wallis test using StatXact 11.0. C. Number of mice exhibiting bilateral tumours representing contralateral spread. Animals were grouped on the basis of overall IGFBP2 induction. * p=0.0136, Fisher Exact test, GraphPad Prism.