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. 1982 Oct;45(10):931–935. doi: 10.1136/jnnp.45.10.931

Plasma and cerebrospinal fluid gamma-aminobutyric acid in neurological disorders.

D Schmidt, W Löscher
PMCID: PMC491600  PMID: 7143013

Abstract

In 49 patients with various neurological disorders plasma and CSF gamma-aminobutyric acid (GABA) concentrations were determined by radioreceptor assay. The CSF GABA concentration of 127 +/- 47 pmol/ml (range: 65-275; n = 52) was independent of the age, the sex and the intake of various drugs including benzodiazepines, baclofen and antidepressants. Patients with diverse neurological disorders such as multiple sclerosis, ischaemic strokes, intracranial tumour and polyneuropathies had similar CSF GABA levels. The mean plasma GABA concentration was 309 +/- 79 pmol/ml (range: 179-498; n = 44). The correlation between the GABA concentrations of CSF and plasma was very poor (r = 0.18; n = 44). Therefore plasma GABA is not a suitable indicator for CSF GABA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbott R. J., Keidan J., Pye I. F., Nahorski S. R. Effect of freezing on gamma-aminobutyric acid levels in human cerebrospinal fluid. J Neurochem. 1981 Oct;37(4):1042–1044. doi: 10.1111/j.1471-4159.1981.tb04493.x. [DOI] [PubMed] [Google Scholar]
  2. Abbott R. J., Pye I. F., Nahorski S. R. CSF and plasma GABA levels in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):253–256. doi: 10.1136/jnnp.45.3.253. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Achar V. S., Welch K. M., Chabi E., Bartosh K., Meyer J. S. Cerebrospinal fluid gamma-aminobutyric acid in neurologic disease. Neurology. 1976 Aug;26(8):777–780. doi: 10.1212/wnl.26.8.777. [DOI] [PubMed] [Google Scholar]
  4. Böhlen P., Huot S., Palfreyman M. G. The relationship between GABA concentrations in brain and cerebrospinal fluid. Brain Res. 1979 May 11;167(2):297–305. doi: 10.1016/0006-8993(79)90824-2. [DOI] [PubMed] [Google Scholar]
  5. Colby B. N., McCaman M. W. A highly specific and sensitive determination of gamma-aminobutyric acid by gas chromatography mass spectrometry. Biomed Mass Spectrom. 1978 Mar;5(3):215–219. doi: 10.1002/bms.1200050309. [DOI] [PubMed] [Google Scholar]
  6. Enna S. J., Stern L. Z., Wastek G. J., Yamamura H. I. Cerebrospinal fluid gamma-aminobutyric acid variations in neurological disorders. Arch Neurol. 1977 Nov;34(11):683–685. doi: 10.1001/archneur.1977.00500230053008. [DOI] [PubMed] [Google Scholar]
  7. Enna S. J., Wood J. H., Snyder S. H. gamma-Aminobutyric acid (GABA) in human cerebrospinal fluid: radioreceptor assay. J Neurochem. 1977 May;28(5):1121–1124. doi: 10.1111/j.1471-4159.1977.tb10676.x. [DOI] [PubMed] [Google Scholar]
  8. Ferkany J. W., Butler I. J., Enna S. J. Effect of drugs on rat brain, cerebrospinal fluid and blood GABA content. J Neurochem. 1979 Jul;33(1):29–33. doi: 10.1111/j.1471-4159.1979.tb11702.x. [DOI] [PubMed] [Google Scholar]
  9. Ferkany J. W., Smith L. A., Seifert W. E., Caprioli R. M., Enna S. J. Measurement of gamma-aminobutyric acid (GABA) in blood. Life Sci. 1978 Jun 19;22(23):2121–2128. doi: 10.1016/0024-3205(78)90456-3. [DOI] [PubMed] [Google Scholar]
  10. Glaeser B. S., Hare T. A. Measurement of GABA in human cerebrospinal fluid. Biochem Med. 1975 Mar;12(3):274–282. doi: 10.1016/0006-2944(75)90129-5. [DOI] [PubMed] [Google Scholar]
  11. Glaeser B. S., Vogel W. H., Oleweiler D. B., Hare T. A. GABA levels in cerebrospinal fluid of patients with Huntington's chorea: a preliminary report. Biochem Med. 1975 Apr;12(4):380–385. doi: 10.1016/0006-2944(75)90070-8. [DOI] [PubMed] [Google Scholar]
  12. Gold B. I., Bowers M. B., Jr, Roth R. H., Sweeney D. W. GABA levels in CSF of patients with psychiatric disorders. Am J Psychiatry. 1980 Mar;137(3):362–364. doi: 10.1176/ajp.137.3.362. [DOI] [PubMed] [Google Scholar]
  13. Grove J., Tell G., Schechter P. J., Koch-Weser J., Warter J. M., Marescaux C., Rumbach L. Increased CSF gamma-aminobutyric acid after treatment with gamma-vinyl GABA. Lancet. 1980 Sep 20;2(8195 Pt 1):647–647. doi: 10.1016/s0140-6736(80)90318-9. [DOI] [PubMed] [Google Scholar]
  14. Hare T. A., Wood J. H., Ballenger J. C., Post R. M. gamma-Aminobutyric acid in human cerebrospinal fluid: normal values. Lancet. 1979 Sep 8;2(8141):534–535. doi: 10.1016/s0140-6736(79)91599-x. [DOI] [PubMed] [Google Scholar]
  15. Huizinga J. D., Teelken A. W., Muskiet F. A., Jeuring H. J., Wolthers B. G. Gamma-aminobutyric acid determination in human cerebrospinal fluid by mass-fragmentography. J Neurochem. 1978 Apr;30(4):911–913. doi: 10.1111/j.1471-4159.1978.tb10802.x. [DOI] [PubMed] [Google Scholar]
  16. Huizinga J. D., Teelken A. W., Muskiet F. A., vd Meulen J., Wolthers B. G. Identification of GABA in human CSF by gas liquid chromatography and mass spectrometry. N Engl J Med. 1977 Mar 24;296(12):692–692. doi: 10.1056/NEJM197703242961216. [DOI] [PubMed] [Google Scholar]
  17. Hyttel J. Characterization of 3H-GABA receptor binding to rat brain synaptosomal membranes: effect of non GABAergic compounds. Psychopharmacology (Berl) 1979 Oct;65(2):211–214. doi: 10.1007/BF00433051. [DOI] [PubMed] [Google Scholar]
  18. Johnston G. A. Neuropharmacology of amino acid inhibitory transmitters. Annu Rev Pharmacol Toxicol. 1978;18:269–289. doi: 10.1146/annurev.pa.18.040178.001413. [DOI] [PubMed] [Google Scholar]
  19. Kuroda H., Ogawa N., Yamawaki Y., Nukina I., Ofuji T., Yamamoto M., Otsuki S. Cerebrospinal fluid GABA levels in various neurological and psychiatric diseases. J Neurol Neurosurg Psychiatry. 1982 Mar;45(3):257–260. doi: 10.1136/jnnp.45.3.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Langer D. H., Brown G. L., Bunney W. E., Jr, van Kammen D. P. Letter: Gamma-aminobutyric acid in CSF in schizophrenia. N Engl J Med. 1975 Jul 24;293(4):201–201. doi: 10.1056/nejm197507242930419. [DOI] [PubMed] [Google Scholar]
  21. Löscher W. GABA in plasma and cerebrospinal fluid of different species. Effects of gamma-acetylenic GABA, gamma-vinyl GABA and sodium valproate. J Neurochem. 1979 May;32(5):1587–1591. doi: 10.1111/j.1471-4159.1979.tb11104.x. [DOI] [PubMed] [Google Scholar]
  22. Löscher W., Schmidt D. Increase of human plasma GABA by sodium valproate. Epilepsia. 1980 Dec;21(6):611–615. doi: 10.1111/j.1528-1157.1980.tb04314.x. [DOI] [PubMed] [Google Scholar]
  23. Manyam N. V., Hare T. A., Katz L. Effect of isoniazid on cerebrospinal fluid and plasma GABA levels in Huntington's disease. Life Sci. 1980 Apr 21;26(16):1303–1308. doi: 10.1016/0024-3205(80)90089-2. [DOI] [PubMed] [Google Scholar]
  24. Manyam N. V., Hare T. A., Katz L., Glaeser B. S. Huntington's disease. Cerebrospinal fluid GABA levels in at-risk individuals. Arch Neurol. 1978 Nov;35(11):728–730. doi: 10.1001/archneur.1978.00500350032006. [DOI] [PubMed] [Google Scholar]
  25. Manyam N. V., Katz L., Hare T. A., Gerber J. C., 3rd, Grossman M. H. Levels of gamma-aminobutyric acid in cerebrospinal fluid in various neurologic disorders. Arch Neurol. 1980 Jun;37(6):352–355. doi: 10.1001/archneur.1980.00500550054006. [DOI] [PubMed] [Google Scholar]
  26. Perlow M. J., Enna S. J., O'Brien P. J., Hoffman H. J., Wyatt R. J. Cerebrospinal fluid gamma-aminobutyric acid: daily pattern and response to haloperidol. J Neurochem. 1979 Jan;32(1):265–268. doi: 10.1111/j.1471-4159.1979.tb04543.x. [DOI] [PubMed] [Google Scholar]
  27. Perry T. L., Hansen S., Kloster M. Huntington's chorea. Deficiency of gamma-aminobutyric acid in brain. N Engl J Med. 1973 Feb 15;288(7):337–342. doi: 10.1056/NEJM197302152880703. [DOI] [PubMed] [Google Scholar]
  28. Wood J. H., Glaeser B. S., Enna S. J., Hare T. A. Verification and quantification of GABA in human cerebrospinal fluid. J Neurochem. 1978 Jan;30(1):291–293. doi: 10.1111/j.1471-4159.1978.tb07068.x. [DOI] [PubMed] [Google Scholar]
  29. Wood J. H., Hare T. A., Glaeser B. S., Ballenger J. C., Post R. M. Low cerebrospinal fluid gamma-aminobutyric acid content in seizure patients. Neurology. 1979 Sep;29(9 Pt 1):1203–1208. doi: 10.1212/wnl.29.9_part_1.1203. [DOI] [PubMed] [Google Scholar]
  30. Wood J. H. Neurochemical analysis of cerebrospinal fluid. Neurology. 1980 Jun;30(6):645–651. doi: 10.1212/wnl.30.6.645. [DOI] [PubMed] [Google Scholar]
  31. Ziegler M. G., Brooks B. R., Lake C. R., Wood J. H., Enna S. J. Norepinephrine and gamma-aminobutyric acid in amyotrophic lateral sclerosis. Neurology. 1980 Jan;30(1):98–101. doi: 10.1212/wnl.30.1.98. [DOI] [PubMed] [Google Scholar]
  32. Zukin S. R., Young A. B., Snyder S. H. Gamma-aminobutyric acid binding to receptor sites in the rat central nervous system. Proc Natl Acad Sci U S A. 1974 Dec;71(12):4802–4807. doi: 10.1073/pnas.71.12.4802. [DOI] [PMC free article] [PubMed] [Google Scholar]

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