Skip to main content
. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Appl Microbiol Biotechnol. 2016 May 28;100(14):6141–6148. doi: 10.1007/s00253-016-7596-3

Figure 1. HQNO inhibits cytochrome b and increases tolerance to antimicrobials.

Figure 1

Figure showing cytoplasmic membrane (CM) of S. aureus. HQNO is a menaquinone analog that inhibits electron transport through cytochrome b. This results in decreased ATP generation and a shift to fermentative metabolism. Reduction of ATP in the cell decreases active transport which is required for uptake of aminoglycoside (AG) antibiotics.