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. 2016 Jun 22;7:182. doi: 10.3389/fphar.2016.00182

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Copyright © 2016 Song, Li, Xia, Gao, Zou, Kong, Yao, Jiao, Yan, Li, Tao, Lian, Yang and Kang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes of gene expression in injured brain after ARC administration. Total RNA was extracted from injured brain tissue at 3 and 7 dpi. mRNA expression of IL-6, IL-10 and TNF-α was examined at 3 dpi, and Bax, Bcl-2, and Caspase-3 were examined at 7 dpi. (A) mRNA expression revealed by RT-PCR. (F) Quantitative analysis of the ratio of Bax/Bcl-2. (B–E) Quantitative analysis of mRNA Levels of TNF-α, IL-6, IL-10, and Caspase-3. ARC administration up-regulated mRNA expression of IL-10, down-regulated mRNA expression of TNF-α, IL-6, and Caspase-3, and reduced the ratio of Bax to Bcl-2 significantly compared to the untreated control. The data are presented as the mean ± SD, n = 6 per group. ^##P < 0.01 vs. naive control; ^∗P < 0.05, ^∗∗P < 0.01, vs. SWI control.