Table 2.
Long-term effect of continuous intravenous β3AR treatment with BRL37344 on hemodynamics in chronic PH
| Baseline | Post-treatment | Change 14 days after intervention | |||||
|---|---|---|---|---|---|---|---|
| Vehicle (N = 4) | BRL37344 (N = 4) | Vehicle (N = 4) | BRL37344 (N = 4) | Vehicle (N = 4) | BRL37344 (N = 4) | p | |
| Weight (kg) | 43.8 (20.6) | 50.8 (19.3) | 57.8 (22.8) | 64.0 (26.9) | 13.5 (5.1) | 12.8 (8.1) | 0.644 |
| SpO2 (%) | 95.0 (3.0) | 92.5 (9.0) | 92.0 (4.0) | 88.5 (7.0) | −3.5 (4.0) | −1.5 (9.0) | 0.715 |
| HR (bpm) | 73.0 (15.0) | 72.5 (14.0) | 77.5 (47.0) | 84.0 (23.0) | 0.5 (53.7) | 15.0 (18.3) | 0.535 |
| Systolic BP (mmHg) | 113.5 (21.0) | 120.0 (21.0) | 118.0 (22.0) | 113.5 (11.0) | 9.5 (10.8) | −4.5 (11.5) | 0.034 |
| Diastolic BP (mmHg) | 76.0 (17.0) | 74.5 (6.0) | 71.0 (28.0) | 74.5 (8.0) | −1.5 (16.3) | 4.0 (7.8) | 0.773 |
| Mean BP (mmHg) | 93.0 (20.0) | 94.0 (13.0) | 93.5 (24.0) | 91.0 (8.0) | 5.0 (12.8) | −0.5 (9.0) | 0.219 |
| Systolic PAP (mmHg) | 38.0 (25.5) | 46.5 (13.5) | 45.8 (20.8) | 40.8 (10.0) | 3.3 (11.4) | −4.5 (12.0) | 0.167 |
| Diastolic PAP (mmHg) | 23.0 (8.3) | 25.5 (6.3) | 30.0 (16.5) | 25.8 (8.4) | 6.0 (13.3) | 1.8 (11.4) | 0.501 |
| Mean PAP (mmHg) | 29.5 (13.0) | 36.0 (8.0) | 38.3 (18.9) | 32.2 (7.9) | 5.8 (11.9) | −0.8 (9.9) | 0.185 |
| Cardiac index (L/min/m2) | 4.4 (1.0) | 4.5 (1.5) | 4.4 (1.4) | 5.3 (2.0) | −0.4 (1.5) | 0.9 (0.6) | 0.042 |
| LV End-diastolic pressure (mmHg) | 8.5 (3.0) | 6.5 (3.0) | 9.5 (8.0) | 9.0 (2.0) | 1.0 (5.8) | 2.0 (2.8) | 0.775 |
| PVRI (WU/m2) | 4.9 (4.2) | 6.5 (3.6) | 6.4 (8.1) | 4.4 (2.7) | 1.5 (4.1) | −2.0 (2.7) | 0.040 |
Values are expressed as median (interquartile range)
SpO 2 oxygen saturation by pulse oximetry, HR heart rate, bpm beats per minute, BP blood pressure, PAP pulmonary artery pressure, PVRI pulmonary vascular resistance index, WU wood units