Table 4.
Long-term effect of selective β3AR agonist treatment with BRL37344 or mirabegron on CMR parameters in chronic PH
| Baseline | Post-treatment | Change | |||||
|---|---|---|---|---|---|---|---|
| Vehicle (N = 10) |
β3AR agonist (N = 10) |
Vehicle (N = 10) |
β3AR agonist (N = 10) |
Vehicle (N = 10) |
β3AR agonist (N = 10) |
p | |
| Weight (kg) | 47.2 (12.3) | 42.7 (18.6) | 57.3 (13.6) | 54.0 (24.3) | 10.2 (5.7) | 12.0 (5.4) | 0.481 |
| HR (bpm) | 67.5 (33.0) | 79.0 (28.0) | 73.0 (22.0) | 85.5 (14.0) | 4.5 (37.5) | 15.0 (18.2) | 0.631 |
| RV end-diastolic volume index (ml/m2) | 99.3 (20.6) | 104.0 (15.5) | 101.4 (16.5) | 92.2 (16.8) | 3.6 (18.2) | −4.0 (26.1) | 0.143 |
| RV end-systolic volume index (ml/m2) | 37.9 (18.4) | 46.6 (16.1) | 43.7 (5.3) | 39.7 (7.0) | 6.5 (15.7) | −5.4 (9.8) | 0.009 |
| LV end-diastolic volume index (ml/m2) | 97.1 (9.5) | 90.3 (17.7) | 93.2 (11.8) | 93.3 (17.3) | −1.4 (16.4) | 3.4 (11.3) | 0.436 |
| LV end-systolic volume index (ml/m2) | 35.5 (11.0) | 36.2 (9.0) | 37.5 (8.7) | 37.2 (11.6) | 1.0 (7.7) | 1.0 (7.7) | 0.971 |
| RV mass index (g/m2) | 28.1 (8.1) | 26.6 (7.6) | 28.1 (8.2) | 27.6 (3.6) | 0.0 (8.3) | 1.9 (8.3) | 0.796 |
| LV mass index (g/m2) | 58.8 (11.4) | 52.6 (9.1) | 62.1 (7.0) | 60.1 (8.3) | −2.1 (17.6) | 7.3 (15.8) | 0.247 |
| RV ejection fraction (%) | 61.9 (13.0) | 52.0 (6.4) | 56.4 (5.6) | 58.4 (7.8) | −3.6 (9.3) | 5.0 (5.2) | 0.007 |
| LV ejection fraction (%) | 63.5 (4.2) | 59.8 (6.1) | 61.9 (6.3) | 61.2 (6.39 | −1.0 (4.6) | 0.6 (6.3) | 0.280 |
| PA average velocity (m/s) | 11.0 (3.3) | 10.5 (4.9) | 11.7 (3.7) | 12.3 (3.2) | 0.9 (2.7) | 1.9 (2.5) | 0.019 |
| PA maximal area (cm2) | 7.0 (1.7) | 7.8 (3.6) | 7.0 (2.9) | 7.5 (2.9) | −0.3 (1.7) | −0.6 (1.5) | 0.089 |
| PA minimal area (cm2) | 4.9 (2.2) | 5.9 (3.2) | 5.3 (2.4) | 5.7 (2.4) | 0.4 (1.5) | −0.3 (2.1) | 0.075 |
Values are expressed as median (interquartile range)
HR heart rate, bpm beats per minute, RV right ventricular, LV left ventricular, PA pulmonary artery, p 1 p value from Student’s t test or Mann–Whitney U test, as adequate; p 2 p value for the time*group interaction term in the repeated measures ANOVA or Mann–Whitney U test of changes, as adequate