Table 1.

MICs of MLSK, tetracycline and fluoroquinolone antibiotics for M. pneumoniae clinical isolates resistant to macrolides and genetically characterized.

	14-membered macrolides		15-membered macrolide		16-membered macrolides		Lincosamides		S.C.	Ketolide	Tetracycline	Fluoroquinolones
Isolates	ERYa	CLA	AZM	JOS	MDM	RKI	LIN	CLI	Q–D	TEL	MIN	CIP	LEV	MXF
Sensitive reference strains M129 (ATCC 29342)	0.004–0.03	0.002–0.015	0.002–0.06	0.03–0.12	0.008–0.06	0.01–0.06	8	4	0.25	0.002	0.25	1	0.12–1	0.03–0.25
CLINICAL STRAINS WITH MUTATION IN DOMAIN V OF 23S rRNA:
A2058Gb	32–>256	32–>256	2–>64	0.06–64	2–>64	0.01–16	>256	16–256	0.06–1	16–>64	0.016–1	0.125–2	0.125–2	<0.008–0.03
A2058C	>256	>256	16	64	64	4	64	32	1	NDc	ND	ND	ND	ND
A2058T	32–64	16–64	0.064–0.25	16	ND	4	ND	256	ND	ND	0.25–1	0.5–1	0.25–1	0.032
A2059G	>64–>256	16–>256	4–64	>64–256	>64–>256	8–32	64	32	0.06–0.25	1–16	0.03–1	0.5–1	0.25–1	0.06–0.12
C2611G	8	1	0.03	0.25	0.25	0.06	16	4	0.25	ND	ND	ND	ND	ND
C2611A	1	0.5	0.03	0.06	ND	0.03	ND	ND	ND	0.06	1	ND	1	0.125

Adapted from Bébéar et al. (2011), Cao et al. (2010), Zhao et al. (2013b), Matsuda et al. (2013), Yamazaki et al. (2007), Pereyre et al (2004b), Waites et al. (2011), Morozumi et al. (2010).

^aERY, erythromycin; CLA, clarithromycin; AZM, azithromycin; JOS, josamycin; MDM, midecamycin; RKI, rokitamycin; LIN, lincomycin; CLI, clindamycin; S.C., Streptogramin combination, Q-D, quinupristin-dalfopristin; TEL, telithromycin; MIN, minocycline; CIP, ciprofloxacin; LEV, levofloxacin; MXF, moxifloxacin.

^bE. coli numbering.

^cND, not determined.