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. 2016 Jun 22;6:153. doi: 10.3389/fonc.2016.00153

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Copyright © 2016 Bagnoli, Granata, Nicoletti, Krishnamachary, Bhujwalla, Canese, Podo, Canevari, Iorio and Mezzanzanica.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Schematic representation of PC cycle and routes of PCho accumulation. (A) Kennedy’s pathway: Cho, choline; Chok, choline kinase; PCho, phosphocholine; CCT, cytidylyltransferase; CDP-Cho, cytidine diphosphate-choline; PCT, phosphocholine phosphotransferase; DAG, diacylglycerol; PC: phosphatidylcholine. Catabolic pathways: PLC, PC-specific phospholipase C; PLD, PC-specific phospholipase D; PLA, PC-specific phospholipases A2 and A1; PD, phosphodiesterase; GPC, glycerophosphocholine; PA, phosphatidate. (B) In the progression from non-tumoral ovarian surface epithelial cells (OSE) or immortalized cell variants (IOSE with an increased replicative potential and IOSE-HTERT with unlimited replicative potential) to EOC cells, there is an evident accumulation of PCho (red arrows) and a decrease of GPC (green arrows).