Figure 1.

Morphology and prognostic impact of myeloid sarcoma vs medullary myeloblast phase of CML. (a) A representative case of MS1+CP: the patient had concurrent MS of skin (left and middle panels) and CML, medullary CP (right panel) as the initial manifestations. (b) A representative case of MS2+CP: the patient had concurrent MS of left tibia (left and middle panels) and CML, medullary CP (right panel) as the late manifestations, 24 months after initial diagnosis of CML-CP. (c) A representative case of MS2+MyBP2: the patient had concurrent MS of right hip (left and middle panels) and CML, medullary MyBP (right panel), 3 months after initial diagnosis of CML-CP. (d) Survival comparison between all CML patients with MS and all patients with medullary MyBP. (e) Survival comparison between subgroups of CML patients with MS arising at different time course of CML treatment. (f) Survival comparison between CML patients with MyBP1 vs patients with MyBP2. (g) Survival comparison between CML patients with MS1+CP vs patients with MyBP1. (h) Survival comparison between CML patients with MS2+CP vs patients with MyBP2. Of these 42 MS patients, 36 were diagnosed and treated at the University of Texas MD Anderson Cancer Center (MDACC) and the remaining 6 in other institutions. All MyBP patients without MS were diagnosed and treated at MDACC. Cases of CML-BP with lymphoblastic or mixed immunophenotype were not included. Survival curves were built using the Kaplan–Meier method, and the differences in survival between subgroups were analyzed by the log-rank test. The study is approved by the Institutional Review Board MDACC. Abbreviations: MyBP1, MyBP at initial diagnosis of CML; MyBP2, MyBP arising later during treatment of CML; MS1, MS at initial diagnosis of CML; MS2, MS arising later during treatment of CML.