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Real-time monitoring by TbIII 2-L1 on the gefitinib inhibition of P1 phosphorylation by protein tyrosine kinase EGFR. (a) The structure of the inhibitor gefitinib. In (b), gefitinib was added to the solution containing P1, MnCl2, EGFR kinase, and TbIII 2-L1, and the reaction was started with addition of ATP. Gray: control without EGFR; red: control without gefitinib. Reproduced with permission from [69]. Copyright 2014, Springer.
