Figure 1.

Pro-angiogenic versus anti-angiogenic miRNAs. Some miRNAs upregulate angiogenesis by promoting angiogenic factors (i.e., VEGF) or by inhibiting anti-antiogenic mediators (i.e., TSP1), while others downregulate angiogenesis by inhibiting anigiogenic molecular pathways. VEGF, vascular endothelial growth factor; TSP1, thrombospondin 1; ZBTB10, zinc finger and BTB domain-containing protein 10; SPRED1, sprout-related EVH1 domain-containing protein 1; PIK3R2, phosphatidylinositol 3-kinase regulatory subunit beta; Sp, substance P; FGF2, fibroblast growth factor; KIT, receptor kinase protein/gene.