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. Author manuscript; available in PMC: 2017 Jul 1.
Published in final edited form as: Am J Med. 2016 Mar 24;129(7):688–698.e2. doi: 10.1016/j.amjmed.2016.02.037

Table 1.

Patient characteristics and outcomes in the training and validation datasets

Training Phase No ALERT (n=126,790) Training Phase ALERT (n=29,317) Validation Phase No ALERT (n=127,078) Validation Phase ALERT (n=29,029)
CHARACTERISTICS
Age 55·2 ± 21·9 63·7 ± 18·1* 55·3 ± 22·0 64·0 ± 18·1*
Female sex 81,153 (64%) 15,086 (51·5%)* 81,062 (63·8%) 14,868 (51·2%)*
Cancer diagnosis 10,835 (8·5%) 4,886 (16·7%)* 10,681 (8·4%) 4,508 (15·5%)*
CABG 438 (0·8%) 500 (1·7%)* 461 (0·4%) 418 (1·4%)*
APACHE score 46·4 ± 20·6 63·8 ± 27·5* 46·1 ± 20·1 65·0 ± 27·9*
Trauma 5,520 (4·4%) 1,476 (5·0%)* 5,990 (4·7%) 1,384 (4·8%)
Cardiac disease 28,819 (22·7%) 8,901 (30·4%)* 27,983 (22·0%) 8,469 (29·2%)*
Cerebrovascular disease 5,833 (4·6%) 1,147 (3·9%) 5,649 (4·5%) 1,183 (4·1%)
COPD 7,402 (5·8%) 3,136 (10·7%)* 8,032 (6·3%) 3,579 (12·3%)*
CKD 5,577 (4·4%) 2,167 (7·4%)* 5,963 (4·7%) 2,035 (7·0%)*
OUTCOMES
ICU length of stay 1·4 ± 1·4 3·4 ± 4·2* 1·3 ± 1·3 3·4 ± 4·2*
Hospital length of stay 3·5 ± 4·0 6·7 ± 6·9* 3·5 ± 3·6 6·4 ± 6·3*
Number of Ventilator days 1·9 ± 1·4 3·8 ± 3·9* 1·7 ± 1·2 3·7 ± 3·7
Angus criteria 6,242 (4·9%) 7,856 (26·8%)* 6,384 (5·0%) 7,888 (27·2%)*
Severe Sepsis 0 (0%) 21,829 (74·5%)* 8838 (9·8%) 20,191 (69·6%)*
Mortality 233 (0·2%) 1,539 (5·2%)* 264 (0·2%) 1,684 (5·8%)*
*

different within phases

different across phases when comparison is made by ALERT status

CABG=coronary artery bypass grafting; COPD= chronic obstructive pulmonary disease; CKD=chronic kidney disease