TABLE 1 .

Vaccine candidates used in this study

Antigen	Function	Inactive form	Reference(s)
ADI	Arginine deiminase.	ADI D277A	7, 12
TF	Ribosome-associated chaperone. Important for protease secretion and activation.		7, 8
SLO	Pore-forming cytolysin. Binds and damages cell membranes, resulting in lysis of the host cell.	SLO P427L W535F	8, 13
SpyCEP	Serine protease cleaves IL-8, interfering with neutrophil recruitment to the site of infection.	SpyCEP D151A S617A	8, 14, 35
SCPA	Subtilisin-like protease. Cleaves C5a, interfering with neutrophil recruitment to the site of infection.	SCPA D130A S512A	8, 15, 33
J8	12-amino-acid peptide from the C-repeat region of M protein.		17, 36, 57, 68
ΔGAC	Group A carbohydrate lacking N-acetylglucosamine (GlcNAc) side chain.		18