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. 2016 Jun 21;7(3):e00830-16. doi: 10.1128/mBio.00830-16

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Copyright © 2016 Mottram et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 1 — Gif^tm1a/tm1a mice exhibit signatures of Cbl deficiency. (a) Immunofluorescence analysis of the glandular stomach regions of wild-type (i) and Gif^tm1a/tm1a (ii) mice stained (red) for the presence of Gif with specific antiserum (×400 magnification). (b) Representative photograph of 8-week-old Gif^tm1a/tm1a and wild-type pups from Gif^tm1a/tm1a (left), Gif^tm1a/+(middle), or wild-type (right) dams. (c) Mean body weights of F₁ Gif^tm1a/tm1a (red triangles), F₂ Gif^tm1a/tm1a (purple triangles), and wild-type (blue circles) mice between 3 and 16 weeks of age. (d) Blood plasma Cbl concentrations Gif^tm1a/tm1a and wild-type mice. Dashed lines show the detection limits of the analyzer. Black bars represent geometric mean values. ***, P < 0.001; **, P < 0.01; *, P < 0.05 (ANOVA with Dunn’s multiple-comparison post hoc test).