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. 2016 Jun 22;6:28287. doi: 10.1038/srep28287

Figure 5. Epitope-specific reactivity for Tfh and NonTfh following vaccination with a heterologous protein containing influenza-derived epitopes.

Figure 5

Shown are the responses of sorted Tfh and NonTfh cells to HA-derived epitopes (a) and NP-derived epitopes (b). As before, mice were vaccinated with the indicated individual MalE133 constructs (5 μg protein) in an IFA/LPS emulsion. Cells were isolated from popliteal lymph nodes pooled from 5 mice per protein at day 9 post vaccination. Eight different MalE133 proteins containing influenza epitopes were constructed. Mean and S.D. of 3–5 experiments. Statistical significance determined by one-tailed paired t test. *p < 0.05; **p < 0.01.