Table 3. Subsequent risks of glaucoma in MGUS, MM, Waldenström, and AL amyloidosis patients.
MGUS | MM | Waldenström | AL amyloidosis | |||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | O | SIR | 95% CI | |||||
All | 512 | 1.60 | 1.47 | 1.75 | 207 | 1.11 | 0.97 | 1.28 | 81 | 1.76 | 1.40 | 2.19 | 118 | 2.18 | 1.81 | 2.62 |
Gender | ||||||||||||||||
Men | 227 | 1.59 | 1.39 | 1.81 | 100 | 1.13 | 0.92 | 1.38 | 48 | 1.94 | 1.43 | 2.57 | 62 | 2.49 | 1.91 | 3.19 |
Women | 285 | 1.61 | 1.43 | 1.81 | 107 | 1.10 | 0.90 | 1.33 | 33 | 1.55 | 1.07 | 2.18 | 56 | 1.92 | 1.45 | 2.50 |
Age at diagnosis (years) | ||||||||||||||||
<60 | 22 | 1.80 | 1.13 | 2.73 | 12 | 1.54 | 0.79 | 2.69 | 4 | 3.20 | 0.83 | 8.27 | 36 | 7.64 | 5.35 | 10.59 |
60–79 | 283 | 1.66 | 1.47 | 1.86 | 120 | 1.13 | 0.93 | 1.35 | 41 | 1.76 | 1.26 | 2.39 | 55 | 1.60 | 1.20 | 2.08 |
80+ | 207 | 1.52 | 1.32 | 1.74 | 75 | 1.05 | 0.82 | 1.31 | 36 | 1.67 | 1.17 | 2.31 | 27 | 1.82 | 1.20 | 2.65 |
Subtype | ||||||||||||||||
Glaucoma suspect (H40.0) | 248 | 1.78 | 1.56 | 2.01 | 83 | 1.09 | 0.87 | 1.36 | 38 | 2.12 | 1.50 | 2.91 | 40 | 1.63 | 1.16 | 2.22 |
Primary open-angle glaucoma (H40.1) | 182 | 1.35 | 1.16 | 1.56 | 84 | 1.01 | 0.81 | 1.26 | 29 | 1.38 | 0.93 | 1.99 | 45 | 2.01 | 1.46 | 2.69 |
Primary angle-closure glaucoma (H40.2) | 8 | 1.85 | 0.79 | 3.66 | 2 | 0.73 | 0.07 | 2.69 | 1 | 1.59 | 0.00 | 9.10 | 1 | 1.27 | 0.00 | 7.26 |
Glaucoma secondary to other eye disorders (H40.5) | 16 | 2.25 | 1.28 | 3.66 | 9 | 2.12 | 0.96 | 4.04 | 2 | 1.80 | 0.17 | 6.63 | 10 | 8.47 | 4.04 | 15.64 |
Other glaucoma (H40.3, H40.4, H40.6, and H40.8) | 4 | 2.45 | 0.64 | 6.35 | 1 | 0.95 | 0.00 | 5.46 | 0 | 9 | 26.47 | 12.00 | 50.47 | |||
Glaucoma, unspecified (H40.9) | 54 | 1.66 | 1.25 | 2.17 | 28 | 1.46 | 0.97 | 2.11 | 11 | 2.10 | 1.04 | 3.78 | 13 | 2.74 | 1.45 | 4.70 |
MGUS: Monoclonal gammopathy of undetermined significance; MM: Multiple myeloma.
O = Observed cases; SIR = Standardized incidence ratio; CI = Confidence intervals.
Bold type: 95% confidence interval does not include 1.00.