Table 1. Inhibitory effects of plumbagin on six CYP isoforms in HLMs and RLMs.

	CYP isoform	IC50 (μM)	Ki (μM)	αKi (μM)	α	Type
Humans	1A2	7.49	0.15	0.16	0.94	non-competitive
	2B6	13.10	1.62	2.92	0.55	mixed-type
	2C9	10.94	2.16	1.46	1.48	mixed-type
	2D6	10.21	1.46	2.22	0.66	mixed-type
	2E1	6.54	0.65	2.64	0.25	mixed-type
	3A4	6.45	0.88	0.57	1.54	mixed-type
Rats	1A2	2.65	2.64	8.51	0.31	mixed-type
	2B1	5.86	9.93	‒	‒	competitive
	2C11	3.85	7.85	‒	‒	competitive
	2D1	6.17	9.49	13.79	0.69	mixed-type
	2E1	3.72	6.28	‒	‒	competitive
	3A2	8.47	‒	‒	‒	atypical kinetics