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. 2016 Jun 22;6:28537. doi: 10.1038/srep28537

Figure 5. Effects of local drug sustained-release delivery (including BMP2, zoledronate and their combination) into bilateral femoral necks on trabecular bone histomorphometry in rabbits subjected to ovariectomy combined with glucocorticoid injection.

Figure 5

(A) Representative tetracycline and calcein double-labeling sections in the regions of femoral necks. Scale bar represents 100 μm for all images. (B~D) Comparisons of dynamic histomorphometric parameters of trabecular bone by double labeling with tetracycline and calcein, including (B) mineral apposition rate (MAR), (C) mineralizing surface per bone surface (MS/BS) and (D) bone formation rate per bone surface (BFR/BS). Control, the control group; OVX + GLU, ovariectomy combined with glucocorticoid injection group; BMP2, OVX + GLU with BMP2 injection group; ZOL, OVX + GLU with zoledronate injection group; BMP2 + ZOL, OVX + GLU with combined injection of BMP2 and zoledronate group. Values are all expressed as mean ± S.D. #Significant difference from the Control group with P < 0.05; *Significant difference from the OVX + GLU group with P < 0.05.