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. 2016 Jun 22;6:28556. doi: 10.1038/srep28556

Figure 2. Accelerated viral clearance and reduced liver damage in LCMV-infected Trem1−/− mice.

Figure 2

(A) At the indicated time-points after LCMV inoculation, livers of Trem1+/+ or Trem1−/− mice were homogenized and the virus titer was determined by the Focus Forming Assay. (B) Reduced viral load of Trem1−/− livers at day 9 and 12 after LCMV inoculation was confirmed by quantitative RT-PCR analysis for the LCMV Z RNA. (C) Frozen liver sections taken at day 9 after LCMV inoculation were stained for the LCMV nucleoprotein with VL4 antibody (green); nuclei were stained with Hoechst 33258 (blue). (D) Protracted ALT elevation in blood plasma of Trem1+/+ mice at day 9 after LCMV inoculation, as compared to Trem1−/− mice. (E) Increased histological activity of Trem1+/+ mice at day 12 after LCMV inoculation, as compared to Trem1−/− mice, determined as the modified histological activity index (mHAI) score. *p < 0.05, **p < 0.01.