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Immunogenicity was assessed via three analytically validated assays: an ELISA for IFN beta1a BAbs, a cell-based assay for peginterferon beta1a NAbs, and an ELISA for anti-PEG Abs.
Ab, antibody; BAb, binding antibody; ELISA, enzyme-linked immunosorbent assay; hIgG, human immunoglobulin G; hIgM, human immunoglobulin M; IFN, interferon; IFNAR, type I IFN receptor; MxA, myxovirus protein A; NAb, neutralizing antibody; PEG, polyethylene glycol.
