Table 2.
Means and standard deviations of raw scores in the different cognitive tests.
| Measure | Baseline |
6-month follow up |
12-month follow up |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fingolimod (n = 22) |
Natalizumab (n = 11) |
Interferon (n = 7) |
Overall (n = 41*) |
Fingolimod (n = 22) |
Natalizumab (n = 11) |
Interferon (n = 7) |
Overall (n = 41*) |
Fingolimod (n = 22) |
Natalizumab (n = 11) |
Interferon (n = 7) |
Overall (n = 41*) |
|
| SPART | 20.14 (5.37) | 20.09 (6.12) | 18.86 (5.55) | 19.72 (5.53) | 21.27 (5.15) | 16.09 (8.13) | 19.71 (5.91) | 19.32 (6.58) | 21.91 (5.02) | 23.82 (5.04) | 23.71 (4.82) | 22.46 (5.23) |
| SPARTDR | 6.95 (2.33) | 6.73 (2.61) | 6.14 (2.04) | 6.68 (2.34) | 6.82 (3.03) | 6.55 (3.30) | 7.71 (2.06) | 6.78 (2.99) | 7.64 (2.36) | 7.64 (2.87) | 8.43 (2.70) | 7.63 (2.64) |
| PASAT-3’ | 43.10 (11.41) | 40.60 (12.69) | 51.57 (4.31) | 45.91 (9.28) | 46.19 (11.14) | 44.55 (11.41) | 49.57 (7.61) | 48.14 (9.33) | 47.62 (11.58) | 49.90 (11.13) | 53.57 (5.97) | 51.63 (7.09) |
| Digit span forward | 7.95 (1.94) | 7.45 (1.51) | 8.429 (2.23) | 7.83 (1.90) | 7.82 (1.87) | 7.36 (1.57) | 8.86 (1.95) | 7.73 (2.03) | 7.86 (1.78) | 7.90 (1.38) | 9.00 (1.41) | 7.93 (1.88) |
| Digit span backward | 6.68 (2.01) | 5.99 (1.18) | 6.43 (2.07) | 6.44 (1.79) | 7.05 (2.03) | 6.18 (1.25) | 7.86 (1.57) | 6.83 (1.96) | 7.18 (1.50) | 6.82 (0.75) | 7.29 (2.29) | 6.98 (1.67) |
| Spatial span forward | 8.32 (2.36) | 7.55 (1.75) | 8.86 (1.46) | 8.1 (2.15) | 9.09 (3.02) | 7.45 (2.11) | 9.00 (1.53) | 8.51 (8.44) | 8.50 (1.85) | 8.45 (1.57) | 8.86 (1.21) | 8.44 (1.78) |
| Spatial span backward | 7.36 (1.99) | 8.18 (2.09) | 9.86 (2.34) | 7.95 (2.25) | 7.59 (2.04) | 7.27 (1.49) | 7.57 (2.23) | 7.41 (1.95) | 7.59 (1.56) | 8.36 (1.75) | 8.71 (1.50) | 7.88 (1.79) |
| Logical memory I | 24.64 (10.49) | 21.36 (5.37) | 21.86 (6.31) | 22.83 (8.96) | 24.05 (8.43) | 22.27 (3.00) | 24.86 (7.22) | 23.22 (7.60) | 20.27 (6.42) | 20.55 (5.41) | 21.86 (2.27) | 20.27 (5.94) |
| Go/Nogo (reaction time) | 559.00 (85.08) | 558.45 (54.63) | 493.29 (51.96) | 549.78 (76.25) | 548.55 (78.10) | 553.91 (61.79) | 510.29 (44.31) | 548.78 (76.86) | 546.95 (71.17) | 559.73 (79.56) | 519.57 (45.72) | 549.46 (72.93) |
| Go/Nogo (errors) | 1.18 (2.59) | 0.27 (0.47) | 0.00 (0.00) | 0.34 (1.74) | 1.50 (3.36) | 0.18 (0.40) | 0.14 (0.38) | 0.54 (1.86) | 0.91 (2.97) | 0.00 (0.00) | 0.14 (0.38) | 1.37 (5.75) |
| Divided attention (omissions) | 3.50 (5.23) | 1.91 (1.87) | 1.71 (2.14) | 2.93 (4.23) | 2.45 (3.63) | 1.55 (1.37) | 1.00 (1.15) | 2.12 (3.03) | 1.55 (2.04) | 1.36 (1.57) | 0.71 (1.11) | 1.73 (3.01) |
| Visual Search (RT) | 900.73 (445.75) | 863.77 (269.58) | 702.17 (93.18) | 862.60 (361.84) | 876.09 (443.01) | 813.92 (162.76) | 791.10 (59.42) | 875.41 (389.39) | 579.32 (104.79) | 538.11 (87.67) | 543.60 (141.32) | 983.61 (436.76) |
| Visual Search (MT ) | 745.33 (106.60) | 645.99 (110.49) | 706.47 (214.72) | 726.62 (165.79) | 705.77 (229.56) | 565.33 (155.12) | 556.43 (139.41) | 651.07 (214.18) | 1040.40 (487.67) | 886.45 (123.70) | 758.65 (41.823) | 578.09 (148.43) |
*
Including the patient treated with glatiramer acetate; MT, movement time; PASAT-3’, Paced Auditory Serial Addition Test 3’; RT, reaction time; SPART, Spatial Recall Test; SPARTDR, delayed recall of the Spatial Recall Test; Go/Nogo, selective-attention test.