Table 2.
Overall survival and treatment-free survival results in 104 patients with CLL
| Variable | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| OS* | ||||
| FISH and KARYO (17pDEL vs NN)† | 8.944 (2.668-29.985) | < .001 | N/A | N/A |
| Rai [high (3,4) vs low (0,1,2)] | 4.144 (1.850-9.284) | .001 | 2.731 (1.136-6.565) | .025 |
| ABSLYM (> median vs ≤ median) | 1.724 (0.786-3.774) | .169 | NS | NS |
| IgVH (nonmutated vs mutated) | 10.000 (1.332-76.923) | .006 | NS | NS |
| ZAP-70 (> 20% vs ≤ 20%) | 1.326 (0.599-2.993) | .486 | NS | NS |
| B2M (> 4 mg/L vs ≤ 4 mg/L) | 4.484 (1.795-11.236) | .001 | NS | NS |
| miR-21 (high vs low) | 2.283 (1.049-4.967) | .033 | 3.474 (1.351-8.938) | .010 |
| miR-181b (low vs high) | 2.348 (1.075-5.102) | .027 | 2.717 (1.106-6.667) | .029 |
| 21FK score (2/2 vs 1/2 vs 0/2)† | 2.869 (1.626-5.062) | < .001 | N/A | N/A |
| TFS‡ | ||||
| FISH and KARYO (17pDEL vs NN)† | 1.182 (0.567-2.464) | .655 | N/A | N/A |
| Rai (high vs low) | 4.797 (2.071-11.113) | < .001 | 4.797 (2.071-11.113) | < .001 |
| ABSLYM (> median vs ≤ median) | 2.049 (0.970-4.329) | .055 | NS | NS |
| IgVH (nonmutated vs mutated) | 2.212 (0.806-6.061) | .114 | NS | NS |
| ZAP-70 (> 20% vs ≤ 20%) | 1.805 (0.809-4.184) | .140 | NS | NS |
| B2M (> 4 mg/L vs ≤ 4 mg/L) | 2.725 (1.175-6.329) | .015 | NS | NS |
| miR-21 (high vs low) | 1.291 (0.628-2.656) | .487 | NS | NS |
| miR-181b (low vs high) | 2.770 (1.295-5.917) | .006 | NS | NS |
HR indicates hazard ratio; CI, confidence interval; FISH, fluorescence in situ hybridization; NN, NORMAL/NORMAL; N/A, not available; ABSLYM, absolute lymphocyte count; NS, not statistically significant; IgVH, immunoglobulin heavy-chain variable-region gene; ZAP-70, 70-kDa ζ-associated protein; B2M, β-2 microglobulin; 21FK, miR-21, FISH, and Karyotype score; and 181bFK, miR-181b, FISH, and Karyotype score.
Complete data are included in supplemental Tables 5-6.
Univariate analysis, n = 99; 5 cases censored before the earliest event in a stratum. Multivariate analysis, n = 86; 4 cases censored before the earliest event in a stratum and 14 cases with missing values.
FISH and KARYO have not been included in multivariate analysis because they were used as criteria to select the patients. In addition, 21FK score has not been included in multivariate analyses because depends from miR-21 expression that was already included. These are indicated as N/A.
Univariate analysis, n = 63; 1 case censored before the earliest event in a stratum and 40 cases with missing values. Multivariate analysis, n = 62; 42 cases with missing values.