Table 1. Tissue-specific Gene Ontology biological processes and KEGG pathways significantly enriched with TSCTs in each tissue.
| Tissue type | Biological process/KEGG pathway | P-value | Count |
|---|---|---|---|
| Testis | Spermatogenesis | 1.96E-06 | 36 |
| Male gamete generation | 1.96E-06 | 36 | |
| Sexual reproduction | 4.37E-05 | 43 | |
| Brain | Neuron differentiation | 6.50E-10 | 42 |
| Neuron projection development | 5.32E-08 | 28 | |
| Alzheimer’s disease | 6.82E-02 | 10 | |
| Monocytes | Immune response | 1.02E-17 | 57 |
| Defense response | 1.48E-16 | 52 | |
| Inflammatory response | 6.96E-12 | 32 | |
| Ovary | Progesterone-mediated oocyte maturation | 2.78E-03 | 7 |
| Heart | Heart contraction | 1.54E-09 | 8 |
| Dilated cardiomyopathy | 1.33E-07 | 11 | |
| Hypertrophic cardiomyopathy (HCM) | 7.53E-07 | 10 | |
| Liver | Oxidation reduction | 2.35E-13 | 33 |
| Steroid metabolic process | 6.01E-13 | 20 | |
| Response to nutrient | 1.35E-02 | 6 | |
| Placenta | Positive regulation of developmental process | 7.04E-03 | 9 |
| Response to nutrient | 1.35E-02 | 6 | |
| Female pregnancy | 2.49E-02 | 5 | |
| Esophagus | Oxidation reduction | 9.42E-04 | 13 |
| Response to protein stimulus | 5.40E-03 | 5 | |
| Glycerolipid metabolism | 5.84E-03 | 4 | |
| B cells | Immune response | 6.50E-06 | 16 |
| Graft-versus-host disease | 2.61E-02 | 3 | |
| Autoimmune thyroid disease | 4.27E-02 | 3 | |
| CD8 + T cell | Immune response | 3.49E-02 | 8 |
| Positive regulation of defense response | 4.28E-02 | 3 | |
| Positive regulation of natural killer cell mediated immunity | 6.98E-02 | 2 | |
| Prostate | Muscle contraction | 5.31E-04 | 6 |
| Gland development | 2.10E-02 | 4 | |
| Colon | Carbohydrate biosynthetic process | 5.36E-03 | 4 |
| Response to nutrient levels | 2.76E-02 | 4 | |
| Response to drug | 3.49E-02 | 4 | |
| Gut | Protein digestion | 1.10E-02 | 2 |
| Multicellular organismal protein catabolic process | 1.10E-02 | 2 | |
| Secretion | 2.46E-02 | 5 | |
| CD4 + T cells | Regulation of Ras protein signal transduction | 3.12E-02 | 3 |
| Regulation of small GTPase mediated signal transduction | 4.35E-02 | 3 |
In this table, columns 1, 2, 3, 4 represent the tissue types, the significantly enriched tissue-specific biological processes or KEGG pathways, the enriched p-values, and the numbers of TSCTs involved in the biological processes or KEGG pathways, respectively.