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. 2016 Jun 22;6:28377. doi: 10.1038/srep28377

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Copyright © 2016, Macmillan Publishers Limited

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When compared to the saline control (denoted by 0), synthetic rat NLP (10, 100 ng/g BW) downregulated preproghrelin (a) and orexin-A (b) mRNA expression in the gut of goldfish. Rat NLP induced no changes in the expression of CART mRNA expression in the gut of goldfish (c). NLP scrambled peptide did not elicit any significant effects on preproghrelin (d,g) or orexin-A (e,h) or CART (f,i) mRNA expression in the hypothalamus or gut. However, the intraperitoneal injection of goldfish NLP (100 ng/g) downregulated preproghrelin (d,g) and orexin-A (e,h) mRNA expression. The mRNA expression data was normalized to 18 s RNA. Asterisks denote significant differences (*p < 0.05) between control and NLP injected groups. One-way ANOVA followed by Tukey’s multiple comparison test was used for statistical analysis. Data are presented as mean + SEM. n = 6–10 fish/group.